Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787446 | 0.83 | MAPT (0.52) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7785114 | 0.81 | SMN1; SMN2 (0.48) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7787584 | 0.80 | MEN1 (0.49) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7785650 | 0.77 | KMT2A (0.50) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7780743 | 0.76 | KMT2A (0.52) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7785476 | 0.75 | MAPT (0.45) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7785132 | 0.75 | SIGMAR1 (0.48) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL27540196 | 0.73 | ACP3 (0.50) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL7785642 | 0.73 | ACP3 (0.50) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL9181124 | 0.73 | ADRB2 (0.39) | SMN1; SMN2TDP1MAPK1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |