Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785313 | 0.89 | GPR88 (0.49) | GPR88ALDH1A1GAALMNAKMT2A | |
| SCHEMBL7789410 | 0.87 | ALDH1A1 (0.57) | ALDH1A1GAALMNAKMT2ATP53 | |
| SCHEMBL7787667 | 0.84 | MAPKAPK2 (0.46) | ALDH1A1GAALMNAKMT2ACYP3A4 | |
| SCHEMBL7780340 | 0.82 | KMT2A (0.42) | ALDH1A1GAALMNAKMT2ATP53 | |
| SCHEMBL7787621 | 0.81 | KMT2A (0.43) | ALDH1A1GAALMNAKMT2ATP53 | |
| SCHEMBL7785656 | 0.81 | ALDH1A1 (0.62) | ALDH1A1GAALMNAKMT2ATP53 | |
| SCHEMBL7785275 | 0.81 | ADRB3 (0.46) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL7780394 | 0.80 | ALDH1A1 (0.67) | ALDH1A1GAALMNAKMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7785230 | 0.80 | GPR88 (0.57) | GPR88ALDH1A1GAALMNAKMT2A | |
| SCHEMBL7785298 | 0.80 | KMT2A (0.44) | ALDH1A1LMNAKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |