Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13335470 | 0.74 | PKM (0.43) | PKMALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL8822948 | 0.73 | HTR6 (0.46) | PKMALDH1A1KDM4EPTGS2POLB | |
| SCHEMBL12415261 | 0.73 | ALDH1A1 (0.49) | PKMALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13791534 | 0.71 | PKM (0.52) | PKMALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL7792399 | 0.70 | POLB (0.57) | PKMALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13388974 | 0.68 | PKM (0.42) | PKMALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL2386652 | 0.66 | PKM (0.66) | PKMALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL7470373 | 0.66 | PKM (0.46) | PKMALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL3279266 | 0.64 | PKM (0.48) | PKMALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL4561817 | 0.64 | PKM (0.48) | PKMALDH1A1SMN1; SMN2L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | L'OREAL S.A. | 2001-09-13 | — | — | US | disclosed |
| US-6248137-B1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo [1,5-a]pyrimidines, method of dyeing and novel 3-aminopyrazolo [1,5-a]pyrimidines | L'OREAL S.A. (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0926149-B1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | OREAL (FR) | 2001-03-07 | — | — | EP | disclosed |
| EP-0926149-A1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | L'OREAL (FR) | 1999-06-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | DPYD, KRT18, PNPO | PKM 791/4885ALDH1A1 443/4885KDM4E 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.