Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7803103 | 0.87 | ADRA1A (0.46) | ADRA1ATAAR1ALDH1A1LMNAP2RX3 | |
| SCHEMBL8439119 | 0.86 | MAP4K4 (0.54) | ADRA1ATAAR1P2RX3AOC3DHFR | |
| SCHEMBL4933784 | 0.85 | MTNR1A (0.47) | ADRA1ATAAR1P2RX3ABCB1AOC3 | |
| SCHEMBL7803101 | 0.84 | CALM1 (0.44) | ADRA1ATAAR1ALDH1A1LMNAP2RX3 | |
| SCHEMBL7796255 | 0.82 | ADRA1A (0.41) | ADRA1ATAAR1P2RX3ABCB1AOC3 | |
| SCHEMBL7796168 | 0.79 | MTNR1B (0.43) | ALDH1A1P2RX3KMT2A | |
| SCHEMBL29923692 | 0.79 | MAPT (0.56) | ENPP1ALDH1A1LMNAEGFRLCK | |
| SCHEMBL591893 | 0.79 | MAPT (0.56) | ENPP1ALDH1A1LMNAEGFRLCK | |
| SCHEMBL7796198 | 0.79 | MTNR1A (0.46) | ADRA1ATAAR1LMNAP2RX3AOC3 | |
| Hydrochloric Acid SCHEMBL28102779 | 0.77 | MAPT (0.55) | ENPP1ALDH1A1LMNAEGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815087-B1 | TRISUBSTITUTED PHENYL DERIVATIVES | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-5990116-A | USE IN PREVENTION OR TREATMENT OF INFLAMMATORY AND PROLIFERATIVE SKIN DISEASES AND CANCER; COMPOUNDS SUCH AS 6-(2-(2,5-DIMETHOXYPHENYL)ETHYL)-4-ETHYL-QUINAZOLINE | NOVARTIS AG (CH) | 1999-11-23 | — | — | US | disclosed |
| EP-0815087-A1 | TRISUBSTITUTED PHENYL DERIVATIVES | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028430-A1 | TRISUBSTITUTED PHENYL DERIVATIVES | NOVARTIS AG (CH) | 1996-09-19 | — | — | WO | disclosed |