Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796295 | 0.98 | TERT (0.44) | KCNA3TERTEGFRALDH1A1L3MBTL1 | |
| SCHEMBL7796098 | 0.87 | L3MBTL1 (0.46) | KCNA3TERTALDH1A1L3MBTL1MAPT | |
| SCHEMBL7786224 | 0.85 | KDM4E (0.53) | KCNA3ALDH1A1L3MBTL1TRPM2PARP1 | |
| SCHEMBL7795762 | 0.84 | KDM4E (0.55) | TERTALDH1A1L3MBTL1TRPM2PARP1 | |
| SCHEMBL7796438 | 0.83 | TRPM2 (0.57) | KCNA3ALDH1A1L3MBTL1TRPM2PARP1 | |
| SCHEMBL7786544 | 0.83 | ALDH1A1 (0.56) | KCNA3ALDH1A1L3MBTL1TRPM2PARP1 | |
| SCHEMBL7795916 | 0.83 | ADORA2A (0.51) | KCNA3EGFRALDH1A1L3MBTL1RAF1 | |
| SCHEMBL7786369 | 0.82 | TRPM2 (0.59) | KCNA3ALDH1A1L3MBTL1TRPM2PARP1 | |
| SCHEMBL7786073 | 0.82 | ADORA2A (0.53) | KCNA3EGFRALDH1A1L3MBTL1RAF1 | |
| SCHEMBL7792617 | 0.76 | KCNA3 (0.43) | KCNA3EGFRALDH1A1L3MBTL1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |