SCHEMBL7795981

SCHEMBL7795981

CN(C)C(=O)Nc1ccccc1-c1ccc(CO)cc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 1/20 0.50
LMNA P02545 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.46
KMT2A Q03164 1/20 0.46
ALDH1A1 P00352 8/20 0.46
HTT P42858 2/20 0.46
KDM4E B2RXH2 1/20 0.46
NPSR1 Q6W5P4 2/20 0.43
MAPT P10636 3/20 0.43
SOAT1 P35610 2/20 0.43
KCNQ2 O43526 1/20 0.43
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7794460 0.88 FABP4 (0.48) FABP4LMNAL3MBTL1MEN1GAA
SCHEMBL10768865 0.85 FABP4 (0.64) FABP4L3MBTL1MEN1KMT2AALDH1A1
SCHEMBL19181534 0.81 ALDH1A1 (0.49) FABP4LMNAL3MBTL1MEN1GAA
SCHEMBL9268258 0.80 ALDH1A1 (0.58) LMNAL3MBTL1MEN1GAAKMT2A
SCHEMBL7785749 0.80 CHRM3 (0.48) LMNAL3MBTL1MEN1GAAKMT2A
SCHEMBL30761772 0.76 ALDH1A1 (0.56) ALDH1A1HTTKDM4ETSHR
SCHEMBL7089269 0.76 ALDH1A1 (0.56) ALDH1A1HTTKDM4ETSHR
SCHEMBL5105758 0.73 ALDH1A1 (0.56) LMNAL3MBTL1MEN1GAAKMT2A
SCHEMBL30295469 0.70 ALDH1A1 (0.63) L3MBTL1GAAALDH1A1HTTMAPT
SCHEMBL1123855 0.70 ALDH1A1 (0.63) L3MBTL1GAAALDH1A1HTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
US-5672596-A ANIMAL GROWTH CONTROLLERS MERCK & CO., INC. (US) 1997-09-30 US disclosed
EP-0659179-A4 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. MERCK & CO INC (US) 1995-08-09 EP disclosed
EP-0659179-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1995-06-28 EP disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO disclosed
US-5283241-A Animal growth regulators MERCK & CO., INC. (US) 1994-02-01 US disclosed