SCHEMBL7798150

SCHEMBL7798150

CCOc1ccccc1CN.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.42
MAPT P10636 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
ALDH1A1 P00352 8/20 0.40
HPGD P15428 1/20 0.40
MAPK1 P28482 1/20 0.38
KDM4E B2RXH2 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2B Q13224 1/20 0.37
HTR7 P34969 1/20 0.37
RXFP1 Q9HBX9 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
AR P10275 1/20 0.36
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
XBP1 P17861 1/20 0.36
HSD17B10 Q99714 1/20 0.36
IDO1 P14902 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzaldehyde SCHEMBL7802566 0.81 L3MBTL1 (0.50) L3MBTL1MAPTNPSR1ALDH1A1HPGD
SCHEMBL7798773 0.79 IDO1 (0.41) ALDH1A1KDM4EGRIN1GRIN2BIDO1
SCHEMBL7800199 0.78 TAAR1 (0.57) ALDH1A1
SCHEMBL31195759 0.76 L3MBTL1 (0.60) L3MBTL1MAPTNPSR1ALDH1A1MAPK1
SCHEMBL469001 0.76 L3MBTL1 (0.60) L3MBTL1MAPTNPSR1ALDH1A1MAPK1
SCHEMBL7800512 0.74 LTA4H (0.47) L3MBTL1MAPTNPSR1ALDH1A1KDM4E
SCHEMBL7802655 0.74 MAOA (0.46) L3MBTL1MAPTNPSR1ALDH1A1KDM4E
SCHEMBL7802629 0.73 MAPT (0.46) L3MBTL1MAPTNPSR1ALDH1A1HPGD
SCHEMBL7801557 0.72 MAOB (0.51) L3MBTL1MAPTALDH1A1HPGDLMNA
SCHEMBL16399775 0.72 ALDH1A1 (0.50) L3MBTL1MAPTALDH1A1HPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076649-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 2001-02-21 EP disclosed
US-6127381-A A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY LION BIOSCIENCE AG (DE) 2000-10-03 US disclosed
WO-1999055679-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 1999-11-04 WO disclosed