Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 4/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 3/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799219 | 0.86 | MME (0.49) | ALDH1A1CA12CA2CA9KMT2A | |
| SCHEMBL7793435 | 0.81 | CA12 (0.52) | POLBALDH1A1CA12CA2CA9 | |
| SCHEMBL7793390 | 0.80 | KMT2A (0.57) | ALDH1A1CA12CA2CA9NPC1 | |
| SCHEMBL7798918 | 0.79 | POLB (0.42) | POLBALDH1A1CA2SMN1; SMN2NPC1 | |
| SCHEMBL7799262 | 0.78 | POLB (0.52) | POLBCA12CA2CA9KMT2A | |
| SCHEMBL7793406 | 0.78 | POLB (0.49) | POLBCA12CA2CA9KMT2A | |
| SCHEMBL7793404 | 0.77 | F10 (0.48) | POLBCA12CA2CA9KMT2A | |
| SCHEMBL7800969 | 0.77 | MMP2 (0.55) | POLBALDH1A1CA12CA2CA9 | |
| SCHEMBL7803203 | 0.77 | POLB (0.51) | POLBCA2KMT2ACYP2D6CYP2C9 | |
| SCHEMBL7793447 | 0.77 | MMP1 (0.64) | POLBPLAAT5PLAAT4ALDH1A1PLAAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143960-A2 | CYSTINE DERIVATIVES AS THERAPEUTIC AGENTS FOR MATRIX METALLOPROTEASE RELATED DISEASES | Roche Diagnostics GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000027378-A2 | CYSTINE DERIVATIVES AS THERAPEUTIC AGENTS FOR MATRIX METALLOPROTEASE RELATED DISEASES | ROCHE DIAGNOSTICS GMBH (DE) | 2000-05-18 | — | — | WO | disclosed |