Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799228 | 0.88 | MME (0.40) | POLBCA2ALDH1A1SMN1; SMN2CA1 | |
| SCHEMBL7798914 | 0.79 | POLB (0.48) | POLBCA2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7803207 | 0.78 | POLB (0.43) | POLBCA2CA1CA5AMMP8 | |
| SCHEMBL7793442 | 0.78 | POLB (0.43) | POLBCA2ALDH1A1CA1CA5A | |
| SCHEMBL7793421 | 0.78 | POLB (0.43) | POLBCA2CA1CA5AMMP8 | |
| SCHEMBL7799269 | 0.78 | MTNR1A (0.45) | POLBCA2CA1CA5AMMP8 | |
| SCHEMBL7798930 | 0.77 | F10 (0.42) | POLBCA2CA1CA5AMMP8 | |
| SCHEMBL7793398 | 0.77 | L3MBTL1 (0.46) | POLBCA2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7793458 | 0.75 | MMP1 (0.49) | POLBGAAALDH1A1SMN1; SMN2MMP9 | |
| SCHEMBL7798895 | 0.74 | NPC1 (0.50) | SMN1; SMN2NPC1RAB9AMMP8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143960-A2 | CYSTINE DERIVATIVES AS THERAPEUTIC AGENTS FOR MATRIX METALLOPROTEASE RELATED DISEASES | Roche Diagnostics GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000027378-A2 | CYSTINE DERIVATIVES AS THERAPEUTIC AGENTS FOR MATRIX METALLOPROTEASE RELATED DISEASES | ROCHE DIAGNOSTICS GMBH (DE) | 2000-05-18 | — | — | WO | disclosed |