Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3085955 | 0.82 | PLA2G1B (0.34) | PLA2G1BPOLBATG4BGAACYP1A2 | |
| SCHEMBL91286 | 0.77 | POLB (0.40) | PLA2G1BPOLBATG4BGAACYP1A2 | |
| SCHEMBL3085952 | 0.72 | PLA2G1B (0.33) | PLA2G1BPOLBATG4BGAACYP1A2 | |
| SCHEMBL19398823 | 0.71 | HSPA5 (0.43) | GAACYP1A2CYP2C9CYP2C19IDO1 | |
| SCHEMBL3700658 | 0.71 | GAA (0.61) | GAACYP2C9CYP2C19DNM1KCNH2 | |
| SCHEMBL21674174 | 0.70 | IDO1 (0.53) | IDO1P2RX7PYCR1MCHR1HTR1A | |
| SCHEMBL12445277 | 0.70 | IDO1 (0.57) | GAACYP1A2CYP2C9CYP2C19IDO1 | |
| SCHEMBL26074534 | 0.70 | S1PR1 (0.41) | GAACYP1A2CYP2C9CYP2C19GSR | |
| SCHEMBL79109 | 0.69 | P2RX7 (0.50) | P2RX7 | |
| SCHEMBL2635160 | 0.69 | PRMT5 (0.37) | PLA2G1BPOLBATG4BGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |