Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 10/20 | 0.57 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PNMT | P11086 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19398823 | 0.82 | HSPA5 (0.43) | IDO1PYCR1TP53CYP2C9CYP2C19 | |
| SCHEMBL24969799 | 0.80 | IDO1 (0.61) | IDO1PYCR1LMNASLC6A4GPR84 | |
| SCHEMBL15784840 | 0.74 | GPR84 (0.42) | IDO1TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL78606 | 0.74 | IDO1 (0.39) | IDO1PYCR1TP53CYP2C19ALDH1A1 | |
| SCHEMBL232137 | 0.73 | IDO1 (1.00) | IDO1TP53CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL12062356 | 0.73 | PNMT (0.46) | IDO1SMN1; SMN2PNMTALOX15TAAR1 | |
| SCHEMBL21302117 | 0.72 | ESR1 (0.40) | IDO1PYCR1GAAMEN1KMT2A | |
| SCHEMBL78610 | 0.72 | LMNA (0.43) | IDO1SMN1; SMN2LMNAPNMTCYP3A4 | |
| SCHEMBL799894 | 0.72 | TP53 (0.48) | TP53SMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL10610735 | 0.70 | ALDH1A1 (0.43) | CYP2C19ALDH1A1LMNATSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895497-B2 | Cathepsin S inhibitors | DCB-USA, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-20110166141-A1 | CATHEPSIN S INHIBITORS | DCB-USA, LLC (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166141-A1 | CATHEPSIN S INHIBITORS | CTSS, CTSV, CTSB | IDO1 1667/4885PYCR1 2965/4885TP53 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.