Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2635160 | 0.79 | PRMT5 (0.37) | POLBPLA2G1BATG4BNPSR1REN | |
| SCHEMBL78001 | 0.77 | PLA2G1B (0.40) | POLBPLA2G1BATG4BCYP1A2CYP2D6 | |
| SCHEMBL2635157 | 0.76 | EPHX2 (0.43) | LMNAKDM4ECYP2D6CYP2C19ALOX15 | |
| SCHEMBL3085952 | 0.76 | PLA2G1B (0.33) | POLBPLA2G1BATG4BLMNAKDM4E | |
| SCHEMBL2635159 | 0.76 | HSD11B1 (0.37) | POLBPLA2G1BATG4BLMNAKDM4E | |
| SCHEMBL3790563 | 0.73 | TRPA1 (0.43) | LMNAKDM4ECYP1A2HTR2ASLC6A4 | |
| SCHEMBL13179975 | 0.72 | L3MBTL1 (0.39) | LMNAKDM4EP4HBNPSR1HTR2A | |
| SCHEMBL3700658 | 0.72 | GAA (0.61) | KDM4ECYP2C9CYP2C19KCNH2SMN1; SMN2 | |
| SCHEMBL24258323 | 0.70 | KMT2A (0.47) | POLBNPSR1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7080588 | 0.70 | IDO1 (0.43) | POLBLMNACYP3A4HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |