Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.59 |
| ▸ | CTSC | P53634 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801689 | 0.84 | ABCG2 (0.67) | CTSCBRAFEGFRABCG2 | |
| SCHEMBL7800595 | 0.81 | LRRK2 (0.46) | IGF1REGFRCDK2CCNA2 | |
| SCHEMBL7757002 | 0.80 | PDGFRB (0.59) | BRAFEGFRCDK2 | |
| SCHEMBL7799220 | 0.80 | ABCG2 (0.65) | BRAFEGFRABCG2CYP1A2CYP3A4 | |
| SCHEMBL7753469 | 0.80 | FGFR1 (0.56) | SYKBRAFEGFRCDK2ABCG2 | |
| SCHEMBL28221880 | 0.80 | PDGFRB (0.64) | SYKBRAFEGFRABCG2CYP1A2 | |
| SCHEMBL7800405 | 0.80 | EGFR (0.56) | SYKEGFRCDK2ABCG2USP2 | |
| SCHEMBL8812882 | 0.78 | PDGFRB (0.57) | BRAFEGFRCDK2 | |
| SCHEMBL27565491 | 0.76 | KDM4E (0.49) | IGF1RBRAFABCG2 | |
| SCHEMBL5309393 | 0.76 | RIPK2 (0.57) | BRAFEGFRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |