Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | IDH2 | P48735 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 6/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801622 | 0.84 | SYK (0.60) | ABCG2EGFRBRAFCTSC | |
| SCHEMBL7757002 | 0.82 | PDGFRB (0.59) | EGFRMAPTBRAFAURKAKDM4E | |
| SCHEMBL7800405 | 0.81 | EGFR (0.56) | ABCG2EGFRMAPTERBB2KDM4E | |
| SCHEMBL7799220 | 0.81 | ABCG2 (0.65) | ABCG2EGFRMAPTMAPK1ERBB2 | |
| SCHEMBL7753469 | 0.81 | FGFR1 (0.56) | ABCG2EGFRMAPTERBB2BRAF | |
| SCHEMBL28221880 | 0.81 | PDGFRB (0.64) | ABCG2EGFRLMNAMAPTMAPK1 | |
| SCHEMBL8812882 | 0.80 | PDGFRB (0.57) | EGFRMAPTBRAFAURKAKDM4E | |
| SCHEMBL15533269 | 0.78 | ABCG2 (0.55) | ABCG2EGFRLMNAMAPTMAPK1 | |
| SCHEMBL7799243 | 0.77 | EGFR (0.58) | EGFRLMNAMAPK1AURKAPTK2 | |
| SCHEMBL27565491 | 0.76 | KDM4E (0.49) | ABCG2MAPTBRAFAURKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |