Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.37 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL16684846 | 0.98 | MEN1 (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL16684870 | 0.95 | MEN1 (0.55) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL4184744 | 0.95 | CYP3A4 (0.62) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2222247 | 0.87 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL780252 | 0.86 | LMNA (0.50) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL356672 | 0.85 | MEN1 (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL119824 | 0.85 | LMNA (0.67) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL16684869 | 0.85 | LMNA (0.48) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL7043034 | 0.83 | MEN1 (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Succinic Acid SCHEMBL3191898 | 0.83 | MEN1 (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2436736-B1 | ORGANOSILOXANE RESIN COMPOSITION AND LAMINATE COMPRISING SAME | TEIJIN CHEMICALS LTD (JP) | 2018-03-28 | — | — | EP | disclosed |
| US-20120070676-A1 | ORGANOSILOXANE RESIN COMPOSITION AND LAMINATE COMPRISING THE SAME | TEIJIN CHEMICALS, LTD. (JP) | 2012-03-22 | — | — | US | disclosed |