Choline

Choline

SCHEMBL780252

C[N+](C)(C)CCO.O=C([O-])CC(=O)O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2

The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
CYP3A4 P08684 1/20 0.50
SLC5A7 Q9GZV3 1/20 0.50
CA4 P22748 2/20 0.38
TSHR P16473 1/20 0.37
APEX1 P27695 2/20 0.36
ALDH1A1 P00352 1/20 0.36
GALR3 O60755 1/20 0.35
BBOX1 O75936 3/20 0.34
SLC22A16 Q86VW1 1/20 0.34
LDHA P00338 1/20 0.33
SRR Q9GZT4 1/20 0.33
CRAT P43155 1/20 0.32
CPT2 P23786 1/20 0.32
CPT1A P50416 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Choline SCHEMBL16684869 0.98 LMNA (0.48) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL16684846 0.89 MEN1 (0.57) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL780251 0.86 LMNA (0.55) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL16684870 0.86 MEN1 (0.55) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL4184744 0.86 CYP3A4 (0.62) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL21380519 0.86 LMNA (0.60) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL4184740 0.84 CYP3A4 (0.65) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL16684873 0.84 LMNA (0.57) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL10630113 0.84 LMNA (0.63) LMNAMEN1KMT2ACYP3A4SLC5A7
Choline SCHEMBL119826 0.84 LMNA (0.63) LMNAMEN1KMT2ACYP3A4SLC5A7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114044852-B Polymerizable eutectic solvent, conductive elastomer and preparation method of conductive elastomer 江南大学 2022-11-22 CN claimed
CN-114044852-A Polymerizable eutectic solvent, conductive elastomer and preparation method thereof 江南大学 2022-02-15 CN claimed
US-20260034075-A1 CHOLINE CARBOXYLIC ACID BASED IONIC LIQUIDS AS ANTIMICROBIAL AGENTS UNIV MISSISSIPPI (US) 2026-02-05 US disclosed
US-12440438-B2 Method of remotely controlling pain Novilla Pharmaceuticals, Inc. (US) 2025-10-14 US disclosed
EP-3503927-B1 TOPICAL FORMULATIONS BASED ON IONIC SPECIES FOR SKIN TREATMENT UNIV CALIFORNIA (US) 2025-02-19 EP disclosed
US-20240156964-A1 IONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY THE ARIZONA BOARD OF REGENTS 2024-05-16 US disclosed
WO-2024044526-A1 RED BLOOD CELL-HITCHHIKING IONIC LIQUID COATED NANOPARTICLES FOR CROSSING THE BLOOD BRAIN BARRIER UNIVERSITY OF MISSISSIPPI (US) 2024-02-29 WO disclosed
WO-2024030844-A1 CHOLINE CARBOXYLIC ACID BASED IONIC LIQUIDS AS ANTIMICROBIAL AGENTS UNIVERSITY OF MISSISSIPPI (US) 2024-02-08 WO disclosed
US-11786597-B2 Ionic liquids for transdermal drug delivery THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-17 US disclosed
US-20230310528-A1 DEEP EUTECTIC SOLVENT INCLUDING ONE OR MORE ACTIVE PHARMACEUTICAL INGREDIENTS DERIVED FROM MUSHROOMS OPTIMI HEALTH CORP (CA) 2023-10-05 US disclosed
CN-109789216-B Topical skin treatment formulations based on ionic species 加利福尼亚大学董事会 2023-05-23 CN disclosed
EP-3503927-A1 TOPICAL FORMULATIONS BASED ON IONIC SPECIES FOR SKIN TREATMENT The Regents of the University of California (US) 2019-07-03 EP disclosed
US-20190192661-A1 TOPICAL FORMULATIONS BASED ON IONIC SPECIES FOR SKIN TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-06-27 US disclosed
EP-2436736-B1 ORGANOSILOXANE RESIN COMPOSITION AND LAMINATE COMPRISING SAME TEIJIN CHEMICALS LTD (JP) 2018-03-28 EP disclosed
WO-2018044920-A1 TOPICAL FORMULATIONS BASED ON IONIC SPECIES FOR SKIN TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-03-08 WO disclosed
US-20160263225-A1 IONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY THE ARIZONA BOARD OF REGENTS 2016-09-15 US disclosed
EP-3062819-A2 IONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY The Regents of The University of California (US) 2016-09-07 EP disclosed
WO-2015066647-A9 IONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-09-17 WO disclosed
WO-2015066647-A2 IONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-05-07 WO disclosed
US-20120070676-A1 ORGANOSILOXANE RESIN COMPOSITION AND LAMINATE COMPRISING THE SAME TEIJIN CHEMICALS, LTD. (JP) 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190192661-A1 TOPICAL FORMULATIONS BASED ON IONIC SPECIES FOR SKIN TREATMENT CUTA, KRT18, SLC38A7 LMNA 984/4885MEN1 3637/4885KMT2A 4681/4885
US-20260034075-A1 CHOLINE CARBOXYLIC ACID BASED IONIC LIQUIDS AS ANTIMICROBIAL AGENTS ELOVL3, L3MBTL3, ELOVL6 LMNA 2830/4885MEN1 1949/4885KMT2A 1535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.