Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL16684846 | 0.98 | MEN1 (0.57) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL780251 | 0.95 | LMNA (0.55) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL16684870 | 0.95 | MEN1 (0.55) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL780252 | 0.86 | LMNA (0.50) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Succinic Acid SCHEMBL6627654 | 0.86 | CYP3A4 (0.62) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL356672 | 0.85 | MEN1 (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL119824 | 0.85 | LMNA (0.67) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL16684869 | 0.85 | LMNA (0.48) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Glycinebetaine SCHEMBL7771556 | 0.84 | CYP3A4 (0.59) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL8816122 | 0.83 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240218101-A1 | CURABLE LIQUID/LIQUID/SOLID MULTIPHASIC SUSPENSIONS | 3M INNOVATIVE PROPERTIES COMPANY | 2024-07-04 | — | — | US | disclosed |
| WO-2023209105-A1 | PROCESS FOR THE RECOVERY OF PLATINUM FROM SPENT PLATINUM-CONTAINING SOLID RESIDUES | FUNDACION TECNALIA RESEARCH & INNOVATION (ES) | 2023-11-02 | — | — | WO | disclosed |
| EP-4269635-A1 | PROCESS FOR THE RECOVERY OF PLATINUM FROM SPENT PLATINUM-CONTAINING SOLID RESIDUES | Fundación Tecnalia Research & Innovation (ES) | 2023-11-01 | — | — | EP | disclosed |
| US-10835999-B2 | Solder flux | UNIVERSITY OF LEICESTER (GB) | 2020-11-17 | — | — | US | disclosed |
| US-20090247647-A1 | Method of Stimulating Proteoglycan Synthesis in Cells | NAVY, SECRETARY OF THE UNITED STATES OF AMERICA | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247647-A1 | Method of Stimulating Proteoglycan Synthesis in Cells | VDR, CYP2R1, CYP27B1 | CYP3A4 3674/4885SLC5A7 2259/4885LMNA 2540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.