Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.32 |
| ▸ | NCF1 | P14598 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL7803531 | 0.69 | ALDH1A1 (0.35) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| Phenylpiperazine SCHEMBL7795027 | 0.65 | GAA (0.46) | TSHRMEN1KMT2AKDM4EHTR3A | |
| SCHEMBL30223071 | 0.65 | HRH4 (0.70) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL24969772 | 0.65 | HRH4 (0.70) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL15195527 | 0.62 | MEN1 (0.47) | CYP1A2HRH4MEN1KMT2AKDM4E | |
| SCHEMBL6559651 | 0.62 | L3MBTL1 (0.40) | CYP1A2CYP3A4HRH4MEN1KMT2A | |
| SCHEMBL15958678 | 0.60 | EGFR (0.49) | MEN1KMT2A | |
| SCHEMBL9216241 | 0.60 | ALDH1A1 (0.62) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL7474377 | 0.59 | NQO2 (0.56) | CYP1A2TSHRHRH4MEN1KMT2A | |
| SCHEMBL17295878 | 0.59 | OPRD1 (0.43) | CYP2D6TSHRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075469-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 2001-02-14 | — | — | EP | disclosed |
| WO-2000052001-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-09-08 | — | — | WO | disclosed |