Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559651 | 0.92 | L3MBTL1 (0.40) | ALDH1A1CYP1A2CYP3A4MAPK1LMNA | |
| SCHEMBL6561301 | 0.79 | KMT2A (0.36) | ALDH1A1CYP1A2CYP3A4LMNAHSD17B10 | |
| SCHEMBL6560382 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TP53CYP1A2LMNAL3MBTL1 | |
| Phenylpiperazine SCHEMBL7795027 | 0.76 | GAA (0.46) | ALDH1A1TSHRHSD17B10L3MBTL1KDM4E | |
| SCHEMBL7803116 | 0.76 | KMT2A (0.46) | ALDH1A1CYP1A2CYP3A4LMNAKDM4E | |
| Piperazine SCHEMBL7803530 | 0.75 | HDAC6 (0.40) | ALDH1A1CYP1A2MAPK1LMNAALOX15 | |
| SCHEMBL6956523 | 0.73 | RAB9A (0.40) | ALDH1A1CYP1A2CYP3A4L3MBTL1HDAC6 | |
| SCHEMBL7795019 | 0.73 | MAPT (0.44) | LMNAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL7803533 | 0.69 | TP53 (0.36) | ALDH1A1TP53CYP1A2CYP3A4TSHR | |
| SCHEMBL7803077 | 0.66 | KDM4E (0.42) | ALDH1A1CYP1A2CYP3A4MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075469-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 2001-02-14 | — | — | EP | disclosed |
| WO-2000052001-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-09-08 | — | — | WO | disclosed |