Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CDC25C | P30307 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006539 | 0.83 | ERN1 (0.57) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL1470136 | 0.81 | TSHR (0.55) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL28013151 | 0.80 | GPR35 (0.53) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL8709893 | 0.80 | THRB (0.56) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL11196837 | 0.80 | CYP1A2 (0.57) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL19742690 | 0.80 | GPR35 (0.53) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL27463698 | 0.80 | SMN1; SMN2 (0.53) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL15283303 | 0.80 | ALDH1A1 (0.56) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL51277 | 0.79 | GPR35 (0.60) | ERN1GPR35ALDH1A1TP53HPGD | |
| SCHEMBL11509750 | 0.78 | APP (0.56) | ERN1GPR35ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0956016-A4 | PHARMACEUTICAL COMPOUNDS COMPRISING POLYAMINES SUBSTITUTED WITH ELECTRON-AFFINIC GROUPS | UNIV FLORIDA STATE (US) | 2001-11-14 | — | — | EP | disclosed |
| US-6255495-B1 | KILLING HYPOXIC TUMOR CELLS AND TREATING DERMATOLOGICAL DISEASES IN WARM-BLOODED ANIMALS VIA ADMINISTERING RADIOSENSITIZING AMOUNT OF ELECTRON-AFFINIC-DIAMINE | FLORIDA STATE UNIVERSITY | 2001-07-03 | — | — | US | disclosed |
| US-6060604-A | FOR RADIOTHERAPY TECHNIQUES, INCREASING TUMOR RADIOSENSITIVITY | FLORIDA STATE UNIVERSITY (US) | 2000-05-09 | — | — | US | disclosed |
| US-6057453-A | OXIDATION, FORMING RADIOSENSITIZING DIAMINES, REDUCTION | FLORIDA STATE UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0956016-A1 | PHARMACEUTICAL COMPOUNDS COMPRISING POLYAMINES SUBSTITUTED WITH ELECTRON-AFFINIC GROUPS | Florida State University (US) | 1999-11-17 | — | — | EP | disclosed |
| CN-1232395-A | Pharmaceutical compounds containing polyamines substituted with electron affinity groups | UNIV FLORIDA STATE (US) | 1999-10-20 | — | — | CN | disclosed |
| WO-1998014190-A9 | PHARMACEUTICAL COMPOUNDS COMPRISING POLYAMINES SUBSTITUTED WITH ELECTRON-AFFINIC GROUPS | — | 1998-07-30 | — | — | WO | disclosed |
| WO-1998014190-A1 | PHARMACEUTICAL COMPOUNDS COMPRISING POLYAMINES SUBSTITUTED WITH ELECTRON-AFFINIC GROUPS | FLORIDA STATE UNIVERSITY (US) | 1998-04-09 | — | — | WO | disclosed |