Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801213 | 0.88 | TDP1 (0.52) | TDP1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7801371 | 0.80 | TDP1 (0.49) | TDP1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7803614 | 0.79 | MAPT (0.46) | TDP1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL28517356 | 0.79 | TDP1 (0.61) | TDP1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL17374954 | 0.77 | TDP1 (0.58) | TDP1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL2962266 | 0.75 | SMN1; SMN2 (0.60) | TDP1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL7780524 | 0.75 | SMN1; SMN2 (0.43) | TDP1HTTHSPB1SMN1; SMN2LMNA | |
| SCHEMBL7804229 | 0.74 | ALDH1A1 (0.42) | TDP1HSPB1KMT2AALDH1A1PTGS2 | |
| SCHEMBL11697350 | 0.73 | HTT (0.55) | TDP1HTTHSPB1SMN1; SMN2LMNA | |
| SCHEMBL16956994 | 0.73 | SMN1; SMN2 (0.57) | TDP1HTTSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |