Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805526 | 0.87 | CASP3 (0.41) | TDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10370846 | 0.85 | POLB (0.44) | TDP1ALDH1A1ATMMAPTHPGD | |
| SCHEMBL10369083 | 0.85 | POLB (0.44) | TDP1ALDH1A1ATMMAPTHPGD | |
| SCHEMBL7860674 | 0.85 | TDP1 (0.45) | TDP1ATMMAPTCCR5RAB9A | |
| SCHEMBL7805407 | 0.85 | ALDH1A1 (0.41) | TDP1ALDH1A1ATMMAPTHPGD | |
| SCHEMBL7858313 | 0.83 | TDP1 (0.41) | TDP1ATMMAPTCCR5RAB9A | |
| SCHEMBL9363149 | 0.82 | TDP1 (0.38) | TDP1ALDH1A1ATMMAPTHPGD | |
| SCHEMBL9363897 | 0.82 | ATM (0.39) | TDP1ALDH1A1ATMMAPTHPGD | |
| SCHEMBL9371889 | 0.82 | L3MBTL1 (0.37) | TDP1ALDH1A1ATMMAPTHPGD | |
| SCHEMBL9363719 | 0.82 | TDP1 (0.40) | TDP1ALDH1A1ATMMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528678-B1 | A pyrrolidylthiocarbapenem derivative with antibacterial activity | SHIONOGI & CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5703243-A | Intermediates for pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5317016-A | Pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-05-31 | — | — | US | disclosed |
| EP-0528678-A1 | A pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |