Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000970 | 0.70 | KDM4E (0.35) | NPC1GAAPOLBKDM4EALDH1A1 | |
| SCHEMBL31467458 | 0.66 | ALDH1A1 (0.44) | GAAPOLBKMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11559781 | 0.65 | TSHR (0.38) | NPC1GAAKDM4EALDH1A1MAPT | |
| SCHEMBL11559777 | 0.65 | TSHR (0.38) | NPC1GAAALDH1A1RAB9A | |
| SCHEMBL19007302 | 0.64 | ALDH1A1 (0.65) | GAAALDH1A1PTGDR2 | |
| SCHEMBL21753597 | 0.64 | KDM4E (0.45) | NPC1GAAPOLBMEN1KMT2A | |
| SCHEMBL4485756 | 0.64 | NPC1 (0.53) | NPC1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL17382016 | 0.63 | LMNA (0.46) | NPC1GAAPOLBALDH1A1MAPT | |
| SCHEMBL28895524 | 0.63 | USP2 (0.54) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL17917631 | 0.63 | ALDH1A1 (0.48) | NPC1GAAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007042-A4 | NOVEL HETEROARYL COMPOUNDS FOR THE MODULATION OF PROTEIN TYROSINE ENZYME RELATED CELLULAR SIGNAL TRANSDUCTION | SUGEN INC (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-1007042-A1 | NOVEL HETEROARYL COMPOUNDS FOR THE MODULATION OF PROTEIN TYROSINE ENZYME RELATED CELLULAR SIGNAL TRANSDUCTION | Sugen, Inc. (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998056376-A1 | NOVEL HETEROARYL COMPOUNDS FOR THE MODULATION OF PROTEIN TYROSINE ENZYME RELATED CELLULAR SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-12-17 | — | — | WO | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |