Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARS1 | P26639 | 1/20 | 0.57 |
| ▸ | LARS1 | Q9P2J5 | 3/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 9/20 | 0.52 |
| ▸ | MMP2 | P08253 | 7/20 | 0.52 |
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792904 | 0.83 | LARS1 (0.78) | TARS1LARS1MMP9MMP13MMP2 | |
| SCHEMBL7163920 | 0.78 | TARS1 (0.54) | TARS1LARS1MMP9MMP13MMP2 | |
| SCHEMBL7815915 | 0.75 | CTSK (0.55) | MMP13CTSKCTSS | |
| SCHEMBL27556168 | 0.74 | TARS1 (0.52) | TARS1LARS1MMP9MMP13MMP2 | |
| SCHEMBL23676433 | 0.73 | LARS1 (0.74) | TARS1LARS1CTSKCTSS | |
| SCHEMBL14602231 | 0.73 | MMP9 (0.82) | TARS1MMP9MMP13MMP2MMP3 | |
| SCHEMBL1798546 | 0.71 | MMP9 (0.67) | TARS1MMP9MMP13MMP2MMP3 | |
| SCHEMBL1798547 | 0.71 | MMP9 (0.67) | TARS1MMP9MMP13MMP2MMP3 | |
| SCHEMBL14217417 | 0.71 | MMP9 (0.74) | TARS1MMP9MMP13MMP2MMP3 | |
| SCHEMBL18019131 | 0.71 | LARS1 (1.00) | TARS1LARS1CTSKCTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |