Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.67 |
| ▸ | MMP13 | P45452 | 7/20 | 0.62 |
| ▸ | ADAMTS4 | O75173 | 6/20 | 0.62 |
| ▸ | MMP2 | P08253 | 6/20 | 0.62 |
| ▸ | MMP3 | P08254 | 3/20 | 0.62 |
| ▸ | MMP1 | P03956 | 3/20 | 0.62 |
| ▸ | MMP7 | P09237 | 1/20 | 0.62 |
| ▸ | TARS1 | P26639 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.50 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798546 | 1.00 | MMP9 (0.67) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL14217417 | 0.88 | MMP9 (0.74) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL6687951 | 0.87 | MMP9 (0.52) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL6687955 | 0.87 | MMP9 (0.52) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL791357 | 0.86 | ADAMTS4 (0.61) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL3687103 | 0.86 | ADAMTS4 (0.61) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL1800250 | 0.84 | MMP13 (0.76) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL1800247 | 0.84 | MMP13 (0.76) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL16000119 | 0.82 | MMP9 (0.68) | MMP9MMP13ADAMTS4MMP2MMP3 | |
| SCHEMBL14602231 | 0.79 | MMP9 (0.82) | MMP9MMP13ADAMTS4MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20090143386-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2009-06-04 | — | — | US | disclosed |
| US-7498358-B2 | e.g. N1-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-D-argininamide; metallopeptidase inhibitor; antiinflammation, anticarcinogenic, antidiabetic agent; angiogenesis inhibitor; atherosclerosis, stroke, ulcer, infertility, scleroderma, endometriosis, mesothelioma | EXELIXIS, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-20050227973-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227973-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, ADAM9 | MMP9 35/4885MMP13 62/4885ADAMTS4 25/4885 |
| US-20090143386-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, CASP10 | MMP9 82/4885MMP13 97/4885ADAMTS4 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.