Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARS1 | P26639 | 1/20 | 0.52 |
| ▸ | LARS1 | Q9P2J5 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 10/20 | 0.47 |
| ▸ | MMP2 | P08253 | 8/20 | 0.47 |
| ▸ | MMP1 | P03956 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792904 | 0.78 | LARS1 (0.78) | TARS1LARS1MMP13MMP2MMP1 | |
| SCHEMBL7806101 | 0.74 | TARS1 (0.57) | TARS1LARS1MMP13MMP2MMP1 | |
| SCHEMBL7163920 | 0.74 | TARS1 (0.54) | TARS1LARS1MMP13MMP2MMP1 | |
| SCHEMBL23676433 | 0.69 | LARS1 (0.74) | TARS1LARS1CTSKCTSS | |
| SCHEMBL20988466 | 0.68 | PGR (0.56) | TARS1MMP13MMP2MMP1MMP9 | |
| SCHEMBL5445424 | 0.67 | MMP2 (0.61) | TARS1MMP13MMP2MMP1MMP9 | |
| SCHEMBL1798546 | 0.67 | MMP9 (0.67) | TARS1MMP13MMP2MMP1MMP9 | |
| SCHEMBL1798547 | 0.67 | MMP9 (0.67) | TARS1MMP13MMP2MMP1MMP9 | |
| SCHEMBL14217417 | 0.66 | MMP9 (0.74) | TARS1MMP13MMP2MMP1MMP9 | |
| SCHEMBL18019131 | 0.66 | LARS1 (1.00) | TARS1LARS1CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1177293-A | Method for inhibiting cathepsin K | SMITHKLINE BEECHAM CORP (US) | 1998-03-25 | — | — | CN | disclosed |