Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805930 | 0.86 | HTR7 (0.51) | ACHEBACE1HTR1AADRA1DADRA1A | |
| SCHEMBL7808760 | 0.85 | HTR1A (0.39) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL7804107 | 0.82 | HTR1A (0.36) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL7804132 | 0.80 | ACHE (0.35) | ACHEBACE1HTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL8031099 | 0.80 | ACHE (0.35) | ACHEBACE1HTR1AADRA1DADRA1A | |
| SCHEMBL9435061 | 0.79 | KCNJ1 (0.52) | ACHEBACE1ADRA1DADRA1AADRA1B | |
| SCHEMBL7804151 | 0.77 | MCHR1 (0.40) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8031232 | 0.76 | MCHR1 (0.39) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL4347857 | 0.76 | HTR1A (0.50) | HTR1AADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL3781560 | 0.73 | GLS (0.53) | ACHENPC1GLSKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |