Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29565874 | 1.00 | GABRA1 (0.39) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL27546472 | 0.95 | GABRA1 (0.36) | GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL7599684 | 0.83 | GABRA1 (0.35) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL6910241 | 0.79 | GABRA1 (0.35) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL27492991 | 0.79 | GABRA1 (0.32) | GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL4946925 | 0.78 | CYP1A2 (0.31) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29612304 | 0.78 | GABRA1 (0.34) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7144896 | 0.78 | GABRA1 (0.34) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| SCHEMBL27464020 | 0.77 | GABRA1 (0.36) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| SCHEMBL27538533 | 0.77 | GABRA1 (0.36) | GABRA1GABRB2TSHRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946748-B | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2011-04-06 | — | — | CN | claimed |
| CN-1946748-A | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV (NL) | 2007-04-11 | — | — | CN | claimed |
| CN-103012623-B | Metalloscene catalyst, its synthesis and purposes in olefin polymerization | NOVOLEN TECH HOLDINGS CV (DE) | 2015-09-16 | — | — | CN | disclosed |
| CN-101384624-B | Catalyst composition for olefin polymerization | NOVOLEN TECH HOLDINGS CV | 2012-07-04 | — | — | CN | disclosed |
| CN-1946748-B | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV | 2011-04-06 | — | — | CN | disclosed |
| CN-101384624-A | Catalyst composition for olefin polymerization | NOVOLEN TECH HOLDINGS CV (NL) | 2009-03-11 | — | — | CN | disclosed |
| CN-1946748-A | Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins | NOVOLEN TECH HOLDINGS CV (NL) | 2007-04-11 | — | — | CN | disclosed |
| CN-1498231-A | Propylene polymer for films | ����ɭ���ڻ�ѧר����˾ | 2004-05-19 | — | — | CN | disclosed |
| EP-1123319-A2 | SUPPORTED POLYMERIZATION CATALYSTS | Borealis Technology (FI) | 2001-08-16 | — | — | EP | disclosed |
| US-20010007009-A1 | Transition metal catalyzed polymerization of olefinic monomers in a water-containing polymerization medium | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-05 | — | — | US | disclosed |
| WO-2000022011-A2 | SUPPORTED POLYMERIZATION CATALYSTS | BOREALIS TECHNOLOGY OY (FI) | 2000-04-20 | — | — | WO | disclosed |
| CN-1246871-A | Propylene polymers incorporating polyethylene macromers | EXXON CHEMICAL PATENTS INC (US) | 2000-03-08 | — | — | CN | disclosed |