SCHEMBL781213

SCHEMBL781213

c1ccc(-c2cc(-c3ccccc3)c3oc4c(-c5ccc6c(c5)c5cc(-c7cc(-c8ccccc8)cc8c7oc7c(-c9ccccc9)cc(-c9ccccc9)cc78)ccc5n6-c5ccc(-c6ccc7c8ccccc8c8ccccc8c7c6)cc5)cc(-c5ccccc5)cc4c3c2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
ATM Q13315 1/20 0.35
PLA2G2A P14555 1/20 0.33
PLA2G4A P47712 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
POLB P06746 1/20 0.33
TSHR P16473 1/20 0.33
BRCA1 P38398 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PRKDC P78527 3/20 0.32
TSPO P30536 1/20 0.32
HDAC4 P56524 1/20 0.32
NR4A2 P43354 1/20 0.31
EDNRB P24530 1/20 0.30
EDNRA P25101 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL781515 0.98 KDM4E (0.40) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL781263 0.95 EDNRB (0.32) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL781236 0.93 PRKDC (0.33) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL780904 0.93 KDM4E (0.36) KDM4EL3MBTL1ATMALDH1A1MEN1
SCHEMBL781316 0.92 PLA2G2A (0.36) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL780996 0.92 KDM4E (0.33) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL781141 0.91 ATM (0.38) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL781093 0.90 KDM4E (0.35) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL781107 0.90 PRKDC (0.39) KDM4EL3MBTL1ATMPLA2G2APLA2G4A
SCHEMBL10165767 0.90 L3MBTL1 (0.47) KDM4EL3MBTL1ATMPLA2G2APLA2G4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-12-29 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 KDM4E 3917/4885L3MBTL1 947/4885ATM 2271/4885
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 KDM4E 3917/4885L3MBTL1 947/4885ATM 2271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.