Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445091 | 0.77 | SIGMAR1 (0.47) | HTTKMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL29413886 | 0.77 | SIGMAR1 (0.47) | HTTKMT2AMEN1NOTUMALDH1A1 | |
| Water SCHEMBL17077293 | 0.75 | SIGMAR1 (0.46) | HTTKMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL1253936 | 0.74 | RAB9A (0.47) | LMNAHTTRAB9AKMT2AMEN1 | |
| SCHEMBL10246639 | 0.71 | LMNA (0.45) | LMNAHTTRAB9AKMT2AMEN1 | |
| SCHEMBL20418273 | 0.71 | LMNA (0.49) | LMNAHTTRAB9AKMT2AMEN1 | |
| SCHEMBL69754 | 0.71 | NOTUM (0.46) | LMNAHTTRAB9AKMT2AMEN1 | |
| SCHEMBL20418099 | 0.71 | LMNA (0.45) | LMNAHTTRAB9AKMT2AMEN1 | |
| SCHEMBL3388501 | 0.71 | LMNA (0.45) | LMNAHTTRAB9AKMT2AMEN1 | |
| SCHEMBL28041864 | 0.71 | RAB9A (0.45) | LMNAHTTRAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109503478-B | 2, 3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivative and preparation method and application thereof | 岭南师范学院 | 2020-04-24 | — | — | CN | disclosed |
| EP-1102754-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007997-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS α1A AGONISTS | ABBOTT LABORATORIES (US) | 2000-02-17 | — | — | WO | disclosed |