Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29413886 | 1.00 | SIGMAR1 (0.47) | SIGMAR1MEN1KMT2AALDH1A1USP2 | |
| Water SCHEMBL17077293 | 0.98 | SIGMAR1 (0.46) | SIGMAR1MEN1KMT2AALDH1A1USP2 | |
| SCHEMBL301140 | 0.89 | SMN1; SMN2 (0.50) | SIGMAR1MEN1KMT2ASMN1; SMN2NOTUM | |
| SCHEMBL28328241 | 0.87 | SMN1; SMN2 (0.46) | SIGMAR1MEN1KMT2ASMN1; SMN2NOTUM | |
| Sulfuric Acid SCHEMBL28331834 | 0.82 | KMT2A (0.51) | SIGMAR1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7812431 | 0.77 | LMNA (0.41) | MEN1KMT2AALDH1A1USP2HTT | |
| SCHEMBL11464258 | 0.72 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL28184962 | 0.70 | SIGMAR1 (0.41) | SIGMAR1MEN1KMT2AALDH1A1USP2 | |
| SCHEMBL8132530 | 0.70 | POLB (0.46) | MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL10716518 | 0.69 | MEN1 (0.42) | SIGMAR1MEN1KMT2AALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321478-A | Synthetic method of 4-fluoro-7-nitroindole or derivative thereof | 上海代为化学科技有限公司 | 2021-02-05 | — | — | CN | claimed |
| CN-107459476-A | Anti- aminated compounds of indole ring third and preparation method thereof, pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2017-12-12 | — | — | CN | claimed |
| CN-102971290-A | Cationic 6-aminoindolines, dyeing compositions containing them, processes and uses thereof | OREAL | 2013-03-13 | — | — | CN | claimed |
| CN-100475818-C | Indolinospiropyran compounds and methods for manufacture | ESSILOR INT (FR) | 2009-04-08 | — | — | CN | claimed |
| CN-101389320-A | Using alpha-hydroxycarbonyl compounds as reducing agents | MORVUS TECHNOLOGY LTD (GB) | 2009-03-18 | — | — | CN | claimed |
| CN-1444586-A | Indolinospiropyran compounds and methods for their manufacture | JOHNSON & JOHNSON VISON CARE I (US) | 2003-09-24 | — | — | CN | claimed |
| EP-3492474-B1 | INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112321478-A | Synthetic method of 4-fluoro-7-nitroindole or derivative thereof | 上海代为化学科技有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-112321478-A | Synthetic method of 4-fluoro-7-nitroindole or derivative thereof | 上海代为化学科技有限公司 | 2021-02-05 | — | — | CN | disclosed |
| US-10562912-B2 | Heterocyclic derivatives and use thereof | C&C RESEARCH LABORATORIES (KR) | 2020-02-18 | — | — | US | disclosed |
| US-10385066-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE LLC (US) | 2019-08-20 | — | — | US | disclosed |
| EP-3492474-A1 | INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GlaxoSmithKline LLC (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20190135829-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2019-05-09 | — | — | US | disclosed |
| US-20020147198-A1 | Substituted arylamine derivatives and methods of use | AMGEN INC. | 2002-10-10 | — | — | US | disclosed |
| WO-2002068406-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | AMGEN INC. (US) | 2002-09-06 | — | — | WO | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |
| CN-1353709-A | Bicyclic oxazolidinones as antibacterial agents | PHARMACIA & UP JOHN CO (US) | 2002-06-12 | — | — | CN | disclosed |
| CN-1063177-C | Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines | BRISTOL MYERS SQUIBB CO (US) | 2001-03-14 | — | — | CN | disclosed |
| CN-1138042-A | Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines | BRISTOL MYERS SQUIBB CO (US) | 1996-12-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385066-B2 | Compounds as diacylglycerol acyltransferase inhibitors | DGAT1, DGAT2, LCAT | SIGMAR1 4834/4885MEN1 3112/4885KMT2A 569/4885 |
| US-20020147198-A1 | Substituted arylamine derivatives and methods of use | NAT1, AADAC, AHR | SIGMAR1 2397/4885MEN1 2237/4885KMT2A 1457/4885 |
| US-10562912-B2 | Heterocyclic derivatives and use thereof | STAT3, JAK2, STAT5A | SIGMAR1 2803/4885MEN1 3206/4885KMT2A 3017/4885 |
| US-20190135829-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | DGAT1, DGAT2, DLAT | SIGMAR1 4752/4885MEN1 3594/4885KMT2A 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.