Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 7/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141861 | 0.92 | EPHX1 (0.44) | SIRT2RAB9AEPHX1NPC1SMN1; SMN2 | |
| SCHEMBL4685971 | 0.88 | SIRT2 (0.43) | SIRT2RAB9AEPHX1NPC1SMN1; SMN2 | |
| SCHEMBL4631995 | 0.86 | SMN1; SMN2 (0.39) | SIRT2RAB9AEPHX1NPC1SMN1; SMN2 | |
| SCHEMBL7837870 | 0.85 | CTSK (0.53) | CTSKCTSS | |
| SCHEMBL7837864 | 0.85 | CTSK (0.53) | CTSKCTSS | |
| SCHEMBL7837866 | 0.85 | CTSK (0.53) | CTSKCTSS | |
| SCHEMBL7278916 | 0.85 | RAB9A (0.42) | RAB9AEPHX1NPC1SMN1; SMN2ACHE | |
| SCHEMBL7278909 | 0.85 | RAB9A (0.42) | RAB9AEPHX1NPC1SMN1; SMN2ACHE | |
| SCHEMBL7382637 | 0.85 | NOD1 (0.48) | SIRT2EPHX1ACHECTSKCTSL | |
| SCHEMBL1077922 | 0.85 | NOD1 (0.48) | SIRT2EPHX1ACHECTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383846-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | Sammut, Ivan Andrew (NZ) | 2018-10-10 | — | — | EP | disclosed |
| WO-2017095237-A1 | CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS | SAMMUT IVAN ANDREW (NZ) | 2017-06-08 | — | — | WO | disclosed |
| EP-0891353-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-08 | — | — | EP | disclosed |
| EP-0891353-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036892-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |