Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812220 | 0.79 | DRD2 (0.64) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| SCHEMBL7814698 | 0.78 | DRD2 (0.60) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| SCHEMBL7805133 | 0.76 | DRD2 (0.55) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| SCHEMBL7818178 | 0.74 | HTR3E (0.52) | DRD2HTR1ADRD3SIGMAR1 | |
| SCHEMBL7820560 | 0.73 | ADRA1D (0.48) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| SCHEMBL7820563 | 0.73 | ADRA1D (0.48) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| SCHEMBL7238114 | 0.68 | HTR2C (1.00) | DRD2HTR2CHTR2ADRD3SIGMAR1 | |
| SCHEMBL13648739 | 0.67 | DRD2 (0.65) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| Ammonia Solution, Strong SCHEMBL2320933 | 0.66 | DRD2 (0.64) | DRD2HTR2CHTR2AHTR1AADRA1D | |
| SCHEMBL19852349 | 0.65 | SIGMAR1 (0.52) | DRD2HTR2CHTR2AHTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |