Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814895 | 0.78 | DRD2 (0.51) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL6963642 | 0.75 | SIGMAR1 (0.86) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7810984 | 0.75 | DRD2 (1.00) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL29639702 | 0.75 | DRD2 (1.00) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7810855 | 0.73 | SIGMAR1 (0.78) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7214291 | 0.73 | DRD2 (0.57) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7805016 | 0.73 | SIGMAR1 (0.78) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7805322 | 0.70 | DRD2 (0.71) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7805320 | 0.70 | SIGMAR1 (0.71) | DRD2SIGMAR1HTR1AADRA2AADRA2C | |
| SCHEMBL7814988 | 0.68 | HTR3E (0.56) | SIGMAR1HTR1AHTR2CHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |