Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820480 | 0.81 | ALOX5 (0.48) | ALOX5LMNAALDH1A1KMT2AGLA | |
| SCHEMBL783749 | 0.80 | NR4A1 (0.50) | ALOX5ALDH1A1GLANR4A2KDM4E | |
| SCHEMBL22645256 | 0.80 | MAPT (0.51) | ALOX5ALDH1A1KMT2AGAACYP2C19 | |
| SCHEMBL3798516 | 0.77 | ALOX5 (0.57) | NPSR1ALOX5LMNAKMT2AKDM4E | |
| SCHEMBL516118 | 0.76 | ALOX5 (0.52) | ALOX5LMNAALDH1A1GLAKDM4E | |
| SCHEMBL4586057 | 0.76 | ALOX5 (0.48) | ALOX5LMNAALDH1A1KMT2AGLA | |
| SCHEMBL28084237 | 0.76 | ALDH1A1 (0.59) | NPSR1ALOX5ALDH1A1KMT2AGLA | |
| SCHEMBL14825579 | 0.76 | ALOX5 (0.48) | ALOX5LMNAALDH1A1KMT2AGLA | |
| SCHEMBL20402334 | 0.75 | ALOX5 (0.55) | NPSR1ALOX5ALDH1A1KMT2ACYP1A2 | |
| Furobufen SCHEMBL30901203 | 0.74 | CYP1A2 (0.58) | NPSR1LMNAALDH1A1CYP1A2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650480-B1 | 1-ARYLSULPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMA CORP (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5684151-A | PROGESTIN AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0650480-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994001412-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |