Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830758 | 0.85 | MMP1 (0.48) | HDAC1SMN1; SMN2NPSR1 | |
| SCHEMBL7830762 | 0.85 | MMP1 (0.48) | HDAC1SMN1; SMN2NPSR1 | |
| SCHEMBL7816268 | 0.82 | HDAC6 (0.40) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7826963 | 0.75 | TTR (0.41) | HDAC1HDAC6HDAC3PARP1GAA | |
| SCHEMBL7826959 | 0.75 | TTR (0.41) | HDAC1HDAC6HDAC3PARP1GAA | |
| SCHEMBL7815811 | 0.73 | NPC1 (0.33) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL7815807 | 0.73 | NPC1 (0.33) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL7815301 | 0.73 | KDM4E (0.42) | HDAC1HDAC6PARP1 | |
| SCHEMBL8068924 | 0.72 | PARP1 (0.38) | PARP1NPSR1 | |
| SCHEMBL7838292 | 0.70 | ALOX15 (0.45) | HDAC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |