Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.48 |
| ▸ | MMP2 | P08253 | 5/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830762 | 1.00 | MMP1 (0.48) | MMP1MMP2MMP9ALDH1A1IMPDH2 | |
| SCHEMBL7827855 | 0.88 | ALDH1A1 (0.50) | ALDH1A1POLBSMN1; SMN2HDAC1GSK3B | |
| SCHEMBL7827848 | 0.88 | ALDH1A1 (0.50) | ALDH1A1POLBSMN1; SMN2HDAC1GSK3B | |
| SCHEMBL7816267 | 0.85 | HDAC1 (0.43) | NPSR1SMN1; SMN2HDAC1 | |
| SCHEMBL8073208 | 0.82 | TRPA1 (0.49) | ALDH1A1NPSR1POLBSMN1; SMN2KDM4E | |
| SCHEMBL8073216 | 0.82 | TRPA1 (0.49) | ALDH1A1NPSR1POLBSMN1; SMN2KDM4E | |
| SCHEMBL7822903 | 0.80 | IAPP (0.38) | GSK3B | |
| SCHEMBL7826959 | 0.79 | TTR (0.41) | ALDH1A1SMN1; SMN2HDAC1GSK3BKDM4E | |
| SCHEMBL7826963 | 0.79 | TTR (0.41) | ALDH1A1SMN1; SMN2HDAC1GSK3BKDM4E | |
| SCHEMBL7815807 | 0.79 | NPC1 (0.33) | SMN1; SMN2HDAC1MAPTLMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |