Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066729 | 0.85 | MAPK1 (0.47) | ALDH1A1LMNAUSP2MAPK1NPSR1 | |
| SCHEMBL7822908 | 0.83 | KDM4E (0.38) | PARP1TSHRALDH1A1LMNAHSD17B10 | |
| SCHEMBL7831864 | 0.82 | KDM4E (0.40) | TLR7ALDH1A1HSD17B10PDE3BPDE3A | |
| SCHEMBL8069019 | 0.80 | PRMT5 (0.39) | PARP1ALDH1A1HSD17B10PDE3BPDE3A | |
| SCHEMBL7826505 | 0.78 | PTGES (0.47) | PARP1TSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL8068238 | 0.77 | MAPT (0.33) | HSD17B10KMT2ATERT | |
| SCHEMBL8066827 | 0.76 | MAPT (0.42) | TSHRALDH1A1LMNAUSP2MAPK1 | |
| SCHEMBL7825628 | 0.76 | PTGES (0.46) | ALDH1A1KMT2A | |
| SCHEMBL7826259 | 0.74 | PTGES (0.51) | ALDH1A1HSD17B10 | |
| SCHEMBL7828601 | 0.74 | PARP1 (0.37) | PARP1ALDH1A1LMNAHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093714-A | AN ANTIALLERGENS FOR TREATMENT AND PREVENTION OF BRONCHIAL ASTHMA, ECZEMA, HIVES, ALLERGIC GASTROINTESTINAL TROUBLES, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-07-25 | — | — | US | disclosed |
| EP-0834512-A1 | TRICYCLIC BENZAZEPINE COMPOUNDS | MEIJI SEIKA KAISHA LTD. (JP) | 1998-04-08 | — | — | EP | disclosed |