Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78506 | 0.85 | L3MBTL1 (0.44) | KMT2AL3MBTL1RAB9AMAPTHPGD | |
| SCHEMBL78439 | 0.80 | L3MBTL1 (0.63) | KMT2AL3MBTL1RAB9AMAPTHPGD | |
| SCHEMBL13165244 | 0.78 | KDM4E (0.41) | KMT2AL3MBTL1RAB9AMAPTHPGD | |
| SCHEMBL10289208 | 0.78 | L3MBTL1 (0.49) | KMT2AL3MBTL1RAB9AMAPTHPGD | |
| SCHEMBL78925 | 0.77 | L3MBTL1 (0.45) | L3MBTL1RAB9AMAPTHPGDTDP1 | |
| SCHEMBL12109478 | 0.76 | ACACB (0.47) | KMT2AL3MBTL1RAB9AMAPTHPGD | |
| SCHEMBL9808263 | 0.75 | L3MBTL1 (0.68) | KMT2AL3MBTL1RAB9AMAPTHPGD | |
| SCHEMBL78449 | 0.75 | SCN8A (0.40) | KMT2ARAB9AMAPTMEN1ALDH1A1 | |
| SCHEMBL270846 | 0.74 | SMN1; SMN2 (0.44) | KMT2ARAB9AMAPTHPGDALDH1A1 | |
| SCHEMBL10223604 | 0.74 | POLB (0.45) | KMT2AL3MBTL1RAB9AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |