Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78925 | 0.86 | L3MBTL1 (0.45) | L3MBTL1HPGDRAB9AGAAMAPT | |
| SCHEMBL78167 | 0.85 | KMT2A (0.54) | L3MBTL1KMT2AHPGDRAB9AGAA | |
| SCHEMBL78449 | 0.84 | SCN8A (0.40) | KMT2ARAB9AMAPTSMN1; SMN2TSHR | |
| SCHEMBL78164 | 0.79 | OXTR (0.34) | L3MBTL1KMT2AHPGDRAB9AMAPT | |
| SCHEMBL78180 | 0.78 | KDM4E (0.46) | L3MBTL1KMT2ARAB9AGAAMAPT | |
| SCHEMBL13165244 | 0.78 | KDM4E (0.41) | L3MBTL1KMT2AHPGDRAB9AMAPT | |
| SCHEMBL78926 | 0.78 | MAPT (0.38) | L3MBTL1KMT2AHPGDRAB9AMAPT | |
| SCHEMBL91185 | 0.78 | L3MBTL1 (0.49) | L3MBTL1KMT2AHPGDRAB9AGAA | |
| SCHEMBL12109478 | 0.76 | ACACB (0.47) | L3MBTL1KMT2AHPGDRAB9AMAPT | |
| SCHEMBL270846 | 0.74 | SMN1; SMN2 (0.44) | KMT2AHPGDRAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |