Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78926 | 0.91 | MAPT (0.38) | L3MBTL1MAPTHPGDMAPK1TDP1 | |
| SCHEMBL78506 | 0.86 | L3MBTL1 (0.44) | L3MBTL1MAPTHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL1750892 | 0.81 | MAPT (0.48) | L3MBTL1MAPTHPGDMAPK1TDP1 | |
| SCHEMBL78168 | 0.80 | L3MBTL1 (0.46) | L3MBTL1MAPTHPGDMAPK1TDP1 | |
| SCHEMBL78449 | 0.78 | SCN8A (0.40) | MAPTSMN1; SMN2KDM4ERAB9APOLB | |
| SCHEMBL3660700 | 0.78 | KDM4E (0.50) | L3MBTL1MAPTHPGDMAPK1TDP1 | |
| SCHEMBL78167 | 0.77 | KMT2A (0.54) | L3MBTL1MAPTHPGDMAPK1TDP1 | |
| SCHEMBL13538059 | 0.77 | MAPT (0.44) | L3MBTL1MAPTHPGDMAPK1TDP1 | |
| SCHEMBL78164 | 0.77 | OXTR (0.34) | L3MBTL1MAPTHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL7716830 | 0.76 | HPGD (0.41) | L3MBTL1MAPTHPGDMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |