Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78506 | 0.84 | L3MBTL1 (0.44) | KDM4ESMN1; SMN2KMT2ATSHRLMNA | |
| SCHEMBL13165244 | 0.79 | KDM4E (0.41) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL78925 | 0.78 | L3MBTL1 (0.45) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL78591 | 0.78 | ALDH1A1 (0.51) | SCN8AALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL12109478 | 0.77 | ACACB (0.47) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL10289285 | 0.77 | MAPT (0.41) | SCN8AALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL270846 | 0.76 | SMN1; SMN2 (0.44) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL10223604 | 0.76 | POLB (0.45) | KDM4EMEN1KMT2ALMNAMAPT | |
| SCHEMBL78167 | 0.75 | KMT2A (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL78164 | 0.74 | OXTR (0.34) | KDM4ESMN1; SMN2KMT2ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |