Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78180 | 0.82 | KDM4E (0.46) | L3MBTL1MAPTTDP1KMT2AMEN1 | |
| SCHEMBL3806966 | 0.82 | TDP1 (0.56) | L3MBTL1MAPTTDP1DRD2DRD4 | |
| SCHEMBL10597748 | 0.81 | L3MBTL1 (0.90) | L3MBTL1MAPTTDP1DRD2DRD4 | |
| SCHEMBL9117427 | 0.81 | L3MBTL1 (0.90) | L3MBTL1MAPTTDP1DRD2DRD4 | |
| SCHEMBL5290069 | 0.81 | L3MBTL1 (0.69) | L3MBTL1MAPTTDP1DRD2DRD4 | |
| SCHEMBL1592400 | 0.81 | DRD2 (0.72) | L3MBTL1MAPTTDP1DRD2DRD4 | |
| SCHEMBL3807523 | 0.81 | RAB9A (0.59) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL78167 | 0.80 | KMT2A (0.54) | L3MBTL1MAPTTDP1DRD2DRD4 | |
| SCHEMBL9320925 | 0.80 | ALDH1A1 (0.48) | L3MBTL1MAPTTDP1KMT2AMEN1 | |
| SCHEMBL5282486 | 0.79 | KDM4E (0.53) | L3MBTL1MAPTDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |