Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3111905 | 0.86 | NOS3 (0.55) | MAPTLMNANPC1RAB9ANFKB1 | |
| Hydrochloric Acid SCHEMBL7827936 | 0.85 | NOS3 (0.54) | MAPTLMNANPC1RAB9ANFKB1 | |
| SCHEMBL7484159 | 0.83 | ALDH1A1 (0.44) | MAPTLMNANPC1RAB9ANFKB1 | |
| SCHEMBL7818530 | 0.82 | MAPT (0.46) | MAPTLMNANPC1RAB9ANFKB1 | |
| Hydrochloric Acid SCHEMBL7832873 | 0.81 | MAPT (0.45) | MAPTLMNANPC1RAB9ANFKB1 | |
| SCHEMBL7817520 | 0.81 | RAB9A (0.44) | MAPTLMNANPC1RAB9ANFKB1 | |
| Hydrochloric Acid SCHEMBL7828292 | 0.80 | RAB9A (0.43) | MAPTLMNANPC1RAB9ANFKB1 | |
| SCHEMBL7511356 | 0.79 | RAB9A (0.45) | MAPTLMNANPC1RAB9ANFKB1 | |
| SCHEMBL7824440 | 0.79 | DRD2 (0.47) | MAPTLMNANPC1RAB9ANFKB1 | |
| Hydrochloric Acid SCHEMBL7510744 | 0.78 | LMNA (0.44) | MAPTLMNANPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983266-B1 | novel tetrahydroisoquinolin thiophenecarboximidamides | ASTRAZENECA AB (SE) | 2001-12-12 | — | — | EP | claimed |
| EP-0983266-A1 | COMPOUNDS | Astra Aktiebolag (SE) | 2000-03-08 | — | — | EP | claimed |
| WO-1998050380-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1998-11-12 | — | — | WO | claimed |
| EP-0983266-B1 | novel tetrahydroisoquinolin thiophenecarboximidamides | ASTRAZENECA AB (SE) | 2001-12-12 | — | — | EP | disclosed |
| US-6166030-A | Compounds | ASTRA AKTIEBOLAG (SE) | 2000-12-26 | — | — | US | disclosed |
| EP-0983266-A1 | COMPOUNDS | Astra Aktiebolag (SE) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050380-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1998-11-12 | — | — | WO | disclosed |