Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030283 | 0.95 | GHSR (0.37) | SLC6A4SLC6A2MBTPS1SLC6A3CYP3A4 | |
| SCHEMBL7826595 | 0.88 | SLC6A4 (0.39) | SLC6A4SLC6A2MBTPS1SLC6A3CYP3A4 | |
| SCHEMBL7844227 | 0.87 | MAPT (0.37) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL7831305 | 0.87 | MAPT (0.37) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL7829393 | 0.87 | SLC6A4 (0.38) | SLC6A4SLC6A2MBTPS1SLC6A3CYP3A4 | |
| SCHEMBL6030139 | 0.86 | ALOX15 (0.37) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL7830301 | 0.85 | AKT1 (0.44) | SLC6A4SLC6A2SLC6A3AKT1MMP2 | |
| SCHEMBL6029579 | 0.84 | MAPK1 (0.37) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL6030272 | 0.84 | CHEK1 (0.37) | SLC6A4SLC6A2MBTPS1SLC6A3CYP3A4 | |
| SCHEMBL6028530 | 0.82 | CHEK1 (0.37) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |