Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831305 | 1.00 | MAPT (0.37) | MAPTPOLBSMN1; SMN2SLC6A4SLC6A2 | |
| SCHEMBL7818522 | 0.87 | SLC6A4 (0.38) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL6030283 | 0.82 | GHSR (0.37) | POLBSLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL6030139 | 0.79 | ALOX15 (0.37) | MAPTSLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL6029579 | 0.78 | MAPK1 (0.37) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL7831249 | 0.76 | SLC6A4 (0.38) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL7826595 | 0.75 | SLC6A4 (0.39) | POLBSLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL7829393 | 0.74 | SLC6A4 (0.38) | MAPTSLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL8177297 | 0.72 | FAAH (0.44) | MAPTPOLBSMN1; SMN2NPBWR1MCHR1 | |
| SCHEMBL7830301 | 0.72 | AKT1 (0.44) | SMN1; SMN2SLC6A4SLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |