Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.49 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630786 | 0.86 | ALDH1A1 (0.51) | MAPTALDH1A1GLACTDSP1MEN1 | |
| SCHEMBL8632712 | 0.85 | P2RX4 (0.48) | MAPTALDH1A1GLACTDSP1NISCH | |
| SCHEMBL8630231 | 0.85 | P2RX4 (0.48) | MAPTALDH1A1GLACTDSP1NISCH | |
| SCHEMBL8630646 | 0.80 | NISCH (0.47) | MAPTALDH1A1NISCHCYP2C19KDM4E | |
| SCHEMBL8630509 | 0.80 | NISCH (0.47) | MAPTALDH1A1NISCHCYP2C19KDM4E | |
| SCHEMBL8627514 | 0.80 | NISCH (0.47) | MAPTALDH1A1NISCHCYP2C19KDM4E | |
| SCHEMBL16804134 | 0.77 | LMNA (0.44) | MAPTALDH1A1GLACTDSP1KMT2A | |
| SCHEMBL11735299 | 0.77 | GLA (0.50) | MAPTALDH1A1GLACTDSP1MEN1 | |
| SCHEMBL8631966 | 0.73 | MAPT (0.56) | MAPTALDH1A1GLACTDSP1MEN1 | |
| SCHEMBL11277121 | 0.72 | MAPT (0.44) | MAPTALDH1A1GLACTDSP1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894796-B1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6057317-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 2000-05-02 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |