Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819783 | 0.77 | MAPT (0.52) | LMNAALDH1A1MAPTGLATSHR | |
| SCHEMBL11269869 | 0.75 | ALDH1A1 (0.41) | LMNAALDH1A1MAPTGLATSHR | |
| SCHEMBL11277121 | 0.75 | MAPT (0.44) | ALDH1A1MAPTGLACTDSP1ATM | |
| Chlozolinate SCHEMBL10638292 | 0.74 | TSHR (0.40) | LMNAALDH1A1MAPTGLATSHR | |
| Chlozolinate SCHEMBL21229 | 0.74 | TSHR (0.40) | LMNAALDH1A1MAPTGLATSHR | |
| Chlozolinate SCHEMBL10347793 | 0.74 | TSHR (0.40) | LMNAALDH1A1MAPTGLATSHR | |
| SCHEMBL11269738 | 0.73 | ALDH1A1 (0.35) | ALDH1A1MAPTGLATSHRCTDSP1 | |
| SCHEMBL11263372 | 0.72 | ALDH1A1 (0.39) | LMNAALDH1A1MAPTGLACTDSP1 | |
| Chlozolinate SCHEMBL747833 | 0.71 | AR (0.40) | LMNAALDH1A1MAPTGLATSHR | |
| SCHEMBL11268442 | 0.70 | MAPT (0.45) | LMNAALDH1A1MAPTGLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505730-B2 | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150166490-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166490-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | NR3C2, MC2R, REN | LMNA 2443/4885ALDH1A1 784/4885MAPT 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.