Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.79 |
| ▸ | HTR2A | P28223 | 5/20 | 0.79 |
| ▸ | HTR1D | P28221 | 4/20 | 0.79 |
| ▸ | HTR1B | P28222 | 4/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | HTR2C | P28335 | 2/20 | 0.79 |
| ▸ | HTR7 | P34969 | 2/20 | 0.79 |
| ▸ | HTR6 | P50406 | 2/20 | 0.79 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.79 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | HTR2B | P41595 | 2/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | MPO | P05164 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9329737 | 0.99 | HTR2A (0.81) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| SCHEMBL8030992 | 0.94 | HTR2A (0.83) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL41982 | 0.88 | HTR1A (1.00) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL29390103 | 0.88 | HTR1A (1.00) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL31109114 | 0.87 | NPSR1 (1.00) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL26617456 | 0.87 | HTR1A (0.97) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL1322980 | 0.87 | NPSR1 (1.00) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL130877 | 0.87 | HTR1A (0.97) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| SCHEMBL5360884 | 0.86 | CYP2D6 (0.79) | HTR1AHTR2AHTR1DHTR1BCYP1A2 | |
| SCHEMBL5363947 | 0.86 | CYP2D6 (0.79) | HTR1AHTR2AHTR1DHTR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077929-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061410-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |