5-Methoxytryptamine

5-Methoxytryptamine

SCHEMBL130877

C.COc1ccc2[nH]cc(CCN)c2c1

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 9/20 0.97
HTR1B P28222 8/20 0.97
HTR1D P28221 7/20 0.97
HTR2A P28223 5/20 0.97
CYP1A2 P05177 2/20 0.97
HTR2C P28335 2/20 0.97
HTR7 P34969 2/20 0.97
HTR6 P50406 2/20 0.97
HTR4 Q13639 2/20 0.97
TRPM8 Q7Z2W7 2/20 0.97
MAPT P10636 1/20 0.97
TSHR P16473 1/20 0.97
NFKB1 P19838 1/20 0.97
BLM P54132 1/20 0.94
PMP22 Q01453 1/20 0.94
NPSR1 Q6W5P4 1/20 0.94
HTR2B P41595 2/20 0.75
MEN1 O00255 1/20 0.74
KMT2A Q03164 1/20 0.74
CYP2D6 P10635 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Methoxytryptamine SCHEMBL41982 0.98 HTR1A (1.00) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL29390103 0.98 HTR1A (1.00) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL26617456 0.97 HTR1A (0.97) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL1322980 0.97 NPSR1 (1.00) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL31109114 0.97 NPSR1 (1.00) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL28309973 0.94 HTR1A (0.91) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL28681558 0.94 HTR1A (0.91) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL27863884 0.93 HTR1A (0.89) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL27863882 0.92 HTR1A (0.86) HTR1AHTR1BHTR1DHTR2ACYP1A2
5-Methoxytryptamine SCHEMBL30812526 0.90 HTR1A (0.84) HTR1AHTR1BHTR1DHTR2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 248 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4618981-A1 COMBINATIONS OF MONOAMINE OXIDASE INHIBITORS AND SEROTONIN RECEPTOR AGONISTS AND THEIR THERAPEUTIC USE Remedi, Inc. (US) 2025-09-24 EP claimed
US-20240390301-A1 COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS GILGAMESH PHARMACEUTICALS, INC. (US) 2024-11-28 US claimed
US-20240252535-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE YZTHERAPEUTIC PERFORMANCE LTD. (IL) 2024-08-01 US claimed
WO-2024108195-A1 COMBINATIONS OF MONOAMINE OXIDASE INHIBITORS AND SEROTONIN RECEPTOR AGONISTS AND THEIR THERAPEUTIC USE REMEDI, INC. (US) 2024-05-23 WO claimed
WO-2024102458-A1 METHODS OF USING TRAZODONE TO REVERSE THE EFFECTS OF 5-HT2A RECEPTOR AGONISTS GILGAMESH PHARMACEUTICALS, INC. (US) 2024-05-16 WO claimed
EP-4208177-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE Yztherapeutic Performance Ltd. (IL) 2023-07-12 EP claimed
WO-2023028086-A1 COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS GILGAMESH PHARMACEUTICALS, INC. (US) 2023-03-02 WO claimed
US-20230024804-A1 PSILOCYBIN COMPOSITIONS TURTLE BEAR HOLDINGS LLC (US) 2023-01-26 US claimed
US-20220160737-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH TURTLE BEAR HOLDINGS LLC (US) 2022-05-26 US claimed
US-20200375967-A1 COMPOSITIONS OF PSILOCYBIN AND ANALOGS TURTLE BEAR HOLDINGS, LLC 2020-12-03 US claimed
WO-2008112773-A2 DROXIDOPA AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF NEURALLY MEDIATED HYPOTENSION CHELSEA THERAPEUTICS, INC. (US) 2008-09-18 WO claimed
US-20080221170-A1 DROXIDOPA AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF FIBROMYALGIA CHELSEA THERAPEUTICS, INC. 2008-09-11 US claimed
EP-1948155-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING DROXIDOPA Chelsea Therapeutics Inc. (US) 2008-07-30 EP claimed
US-20080015181-A1 Pharmaceutical Compositions Comprising Droxidopa CHELSEA THERAPEUTICS, INC. 2008-01-17 US claimed
WO-2008003028-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING DROXIDOPA CHELSEA THERAPEUTICS, INC. (US) 2008-01-03 WO claimed
EP-1112106-B1 SEROTONERGIC 5HT2 AGONISTS FOR TREATING GLAUCOMA ALCON MFG LTD (US) 2005-11-23 EP claimed
US-6664286-B1 Lower and control elevated intraocular pressure ALCON MANUFACTURING, LTD. 2003-12-16 US claimed
US-20030203912-A1 Serotonergic 5HT2 agonists for treating glaucoma MAY JESSE A (US) 2003-10-30 US claimed
EP-1112106-A2 SEROTONERGIC 5HT2 AGONISTS FOR TREATING GLAUCOMA ALCON LABORATORIES, INC. (US) 2001-07-04 EP claimed
WO-2000016761-A2 SEROTONERGIC 5HT2 AGONISTS FOR TREATING GLAUCOMA ALCON LABORATORIES, INC. (US) 2000-03-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080015181-A1 Pharmaceutical Compositions Comprising Droxidopa COMT, ACHE, MAOA HTR1A 83/4885HTR1B 91/4885HTR1D 152/4885
US-20240390301-A1 COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS HTR2A, HTR2C, HTR5A HTR1A 4/4885HTR1B 8/4885HTR1D 13/4885
US-20200375967-A1 COMPOSITIONS OF PSILOCYBIN AND ANALOGS PNMT, NES, GAP43 HTR1A 127/4885HTR1B 55/4885HTR1D 112/4885
US-20220160737-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, HTR6, BDNF HTR1A 13/4885HTR1B 1/4885HTR1D 15/4885
US-20230024804-A1 PSILOCYBIN COMPOSITIONS NES, PNMT, GAP43 HTR1A 160/4885HTR1B 64/4885HTR1D 170/4885
US-20080221170-A1 DROXIDOPA AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF FIBROMYALGIA HTR5A, FAAH, MTNR1B HTR1A 7/4885HTR1B 36/4885HTR1D 29/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.